A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.
Grissom is confronted with new evidence while on the stand of a murder trial of a restaurant owner. This development requires the reopening of the case and Eckley initiates an inquiry into Grissom and his team. The results of the inquiry lead to dramatic changes of the CSI team and the series.
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