Cu locația în Springfield, orașul tipic american, povestea se concentrează pe aventurile ridicole ale familiei Simpson; Homer, Marge, Bart, Lisa și Maggie, dar și pe o distribuție de alte câteva sute de personaje.
De la început, seria a devenit un simbol cultural, atrăgând sute de vedete care și-au făcut apariția ca invitați. Serialul și-a făcut un nume prin satira fără frică asupra politicii, mediei și vieții americane în general.
Feeling worthless at work, Homer volunteers to be a school crossing guard. But when his safety squad receives too much funding, the crossing guards become a force to be feared.
When a new neighbor showers him with kindness, Homer thinks he's being tricked into buying a sports car at the dealership where the neighbor works - but the truth turns out to be even more sinister; Lisa neutralizes Nelson after he goes on a bullying spree.
In a parody documentary, a young college-dropout CEO embraces the Silicon Valley "fake it until you make it" philosophy and bewitches Mr. Burns into funding her highly dubious dream project.
After Bart is turned into an NFT, Marge fights though the blockchain to rescue her son. To track down a gruesome serial killer, Lisa turns to a murderer from her past. An outbreak transforms Springfielders into a plague of lazy, beer-loving oafs.
When Marge's heart is broken by a bad birthday present, Bart and Lisa must dig into their mom's past to show that they really know her. Homer becomes a neighborhood fear-monger.
Professor Frink secretly helps Homer, through a zoom interview, land a high-level position at a state-of-the-art nuclear plant in Shelbyville. But since Homer lacks the skills to actually perform the job, Frink must monitor Homer's work situation remotely and dictate his every word... causing Frink to fear he's created a monster.
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